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- W2378087152 abstract "To investigate the effect of 12C6+ ions radiation on the cell cycle and the expression of P53, MDM2 and P21 of SMMC-7721 cells. SMMC-7721 cells were irradiated with 12C6+ ions with the doses of 0Gy, 1.0Gy, 2.0Gy, 4.0Gy or 6.0Gy, then dose-survival curve of SMMC-7721 cells was figured by colony-forming assay. At 24h after ir- radiation cell cycle was analyzed by FACS and the expressions of P53, MDM2 and P21 were detected by West- ern-blot Assay. Results showed that the percentage of survival SMMC-7721 cells decreased with irradiation doses. The percentage of cells in G0/G1 phase increased after 1.0Gy, 4.0Gy, 6.0Gy 12C6+ ions irradiation compared with that of the control group. However, 2.0Gy 12C6+ ions irradiation increased the percentage of cells in G2/M phase. Com- pared to control, there were no changes in the expression of 57kD MDM2 in irradiated groups, but the expression levels of 76kD MDM2, P53 and P21 increased with irradiation doses. Therefore, the different doses of 12C6+ ions ir- radiation can activate different cell cycle checkpoints. The increased percentages of cells in G0/G1 phase were associ- ated with the high expression levels of P53, P21 and 76kD MDM2 proteins." @default.
- W2378087152 created "2016-06-24" @default.
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- W2378087152 date "2006-01-01" @default.
- W2378087152 modified "2023-09-22" @default.
- W2378087152 title "Chanres in cell cycle and expression of P53,MDM2 and P21 in SMMC-7721 cells irradiated by ~(12)C~(6+) ions" @default.
- W2378087152 hasPublicationYear "2006" @default.
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