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- W2378091372 abstract "Objective To investigate the efficacy and safety of individual anti-tuberculous chemotherapy guided by drug susceptibility testing for spinal tuberculosis by analyzing the post-operative follow-up outcomes. Methods In this series,the diagnoses of spinal tuberculosis were established based on clinical,radiological and histological arguments in 46 patients who were admitted from August 2005 to March 2009. Their specimens ( pus or caseous tissue) were collected during surgery. After processed in a routine mycobacteriology laboratory procedure,the specimens were inoculated into vials of the BACT/ALERT 3D system. The drug susceptibility testing was performed using absolute concentration method,which included 11 first and second line drugs. Four or five anti-tuberculous drug regimen was chosen according to the results of drug susceptibility testing. All the patients were followed up regularly a month later,and then every 3 months for the following 11 months,and subsequently at intervals of half a year. The clinical status,erythrocyte sedimentation rate ( ESR) ,roentgeno-gram and 3D-CT were concerned to estimate the progress of tuberculosis. Radiographs were analyzed before sur-gery,immediately after surgery,and at the final follow-up examination to assess the result of anterior fusion and maintenance of correction. Results Nineteen of the total 46 specimens were culture positive ( 41. 3% ) . The average detection time to report drug susceptibility was 42 d ( ranging from 30 to 58 d) . The drug susceptibility testing showed a resistance level of 10. 8% for isoniazid,2. 1% for rifampicin and ethambutol,6. 52% for streptomycin,4. 34% for dipasic and 17. 396% for levofloxacin. Four patients with gastrointestinal reaction and 1 with anti-tuberculosis drug-induced hepatitis completed a 12 months’therapy,and the others received a 18 month’therapy. The mean follow-up period was 25 months ( ranging from 18 to 44 months) ,and no obvious loss of deformity correction was observed. According to Bridwell criteria,grade Ⅰbony fusion was obtained in all patients in 9 to 12 months. Conclusion If guided by drug susceptibility testing,individual anti-tuberculous chemotherapy for 12 to 18 months is effective and safe for spinal tuberculosis,." @default.
- W2378091372 created "2016-06-24" @default.
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- W2378091372 date "2009-01-01" @default.
- W2378091372 modified "2023-09-24" @default.
- W2378091372 title "Drug susceptibility-guided individual anti-tuberculous chemotherapy for spinal tuberculosis: report of 46 cases" @default.
- W2378091372 hasPublicationYear "2009" @default.
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