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- W2378091736 abstract "Objective To investigate the change of serum remnant like particle cholesterol (RLP C) and the association of RLP C with diabetic nephropathy (DN) in the patients with type 2 diabetes mellitus (DM). Methods Serum RLP C concentration was assayed by immunoseparation method. Plasma α granule membrane glycoprotein 140 (GMP140) and nitric oxide (NO) levels were also measured. Urinary albumin excretion rate (UAER) was measured by radioimmunoassay, and the patients with type 2 DM were assigned to three groups according to UAER 〔35 without DN (D 1 group, UAER20 μg/min), 33 with microalbuminuria (D 2 group, UAER 20 200 μg/min), and 28 with macroalbuminuria (D 3 group, UAER200 μg/min)〕. Results Serum RLP C concentration in 96 patients with type 2 DM was significantly increased compared to that in 44 normal controls (NC) 〔(0.281±0.162)mmol/L vs (0.193±0.125)mmol/L, P0.01〕. Among D 1, D 2, D 3 groups, RLP C concentrations were gradually increased 〔(0.225±0.145)mmol/L, (0.292±0.181)mmol/L, (0.363±0.192)mmol/L〕. The levels of GMP140 were significantly higher in D 2 group and D 3 group than those in NC group and D 1 group (P0.01). NO levels were markedly elevated in NC group and D 1 group compared to those in D 2 group and D 3 group (P0.01). RLP C concentration was positively correlated with level of GMP140 (r=0.81, P0.01) andUAER(r=0.78, P0.01),andwasnegativelycorrelatedwithNO level (r=-0.75, P0.01). There wassignificantlynegativecorrelationbetweenNOlevel and level of GMP140 (r=-0.78, P0.01). Conclusion Serum RLP C concentration is significantly increased in type 2 DM patients, especially in type 2 DM patients with DN. RLP C may play an important role in the pathogenesis of DN and seems to be involved in endothelial dysfunction and platelet activation." @default.
- W2378091736 created "2016-06-24" @default.
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- W2378091736 date "2005-01-01" @default.
- W2378091736 modified "2023-10-13" @default.
- W2378091736 title "Serum remnant-like particle cholesterol concentration and its clinical significance in the patients with type 2 diabetes mellitus" @default.
- W2378091736 hasPublicationYear "2005" @default.
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