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- W2378093407 abstract "Objective To study the mechanism of growth associated protein-43(GAP-43) involved in neurogenesis,in order to verify the hypothesis that GAP-43 may influence the orientation of cell division through interacting with G proteins.Methods The experiment was divided into two groups,the experimental and control groups.Six C57BL/6J GAP-43 transgenic pregnant mice(24 fetuses of E13.5 and E17.5 days) were as the experimental group,and six wild-type pregnant mice(24 fetuses of E13.5 and E17.5 days) were as the control group.The localization of GAP-43 was determined by immunofluorescence and Western blot,while the interaction of GAP-43 and Gαi were detected by co-immunoprecipitation(co-IP).Furthermore,in order to compare the orientation of cell division in fetal brains of the transgenic mice with that in wild type mous,we measured the exact angle of the dividing chromatics in regard to the ventricular zone during neurogenesis.Results Respectively selected 24 embryonic mice of embryonic period of 13.5 and 17.5 in each group(transgenic and wild type groups).The Western blot and immunofluorescence results showed that the expression of GAP-43 was higher in transgenic groups than those in wild type groups and was on the membrane in both two groups(P0.05).The co-IP result showed that GAP-43 interacted with Gai.The analysis of the exact angle of the dividing chromatics revealed a significant difference in dividing cells in the transgenic group compared with the wild type group of E13.5(P0.05).Conclusion The GAP-43 is involved in the orientation of cell division through Gai and this may be an important mechanism for neurogenesis in the mammalian brain.This study provides the foundation of the mechanism of GAP-43 in neurogenesis and stroke for further study." @default.
- W2378093407 created "2016-06-24" @default.
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- W2378093407 date "2015-01-01" @default.
- W2378093407 modified "2023-09-23" @default.
- W2378093407 title "Growth Associated Protein-43 Influences the Orientation of Cell Division in the Brain" @default.
- W2378093407 hasPublicationYear "2015" @default.
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