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- W2378096550 abstract "Objective To investigate the protective effect of down-regulation of phosphatase and tensin homology (PTEN) deleted on chromosome ten on neuron injury of rats after global cerebral ischemia and reperfusion.Methods Sixty SD rats were assigned randomly into three groups (20 each):normal group (liposome trasnfected),pshGFP group (isolated control) and pshRNApten group (pshRNApten transfected).Rats in each group was inflicted with cerebral ischemia and reperfusion of the brains,and they were treated at three time points,i.e.3d (n=6),7d (n=7) and 14d (n=6) after reperfusion.Plasmid pshRNApten was injected into hippocampus of rats in pshRNApten group,liposome and plasmid pshGFP were injected in normal group and pshGFP group,respectively.Two days after injection,global cerebral ischemia and reperfusion model was reproduced by four-artery ligation.PTEN expression in neuron of hippocampus was detected by RT-PCR and immunohistochemistry.The neuron injury was determined by HE and Nissl's staining,and the neuron apoptosis was detected by terminal deoxynucleotidy transferase UTP-nick end labeling (TUNEL).Results The mRNA and protein expression of PTEN decreased obviously in pshRNApten group than in normal group (P0.05).Nissl's and HE staining showed that the neuronal damage and degeneration in hippocampus after global ischemia and reperfusion (I/R) were more severe in PshGFP group than in pshRNApten group.There was a significant decrease in the number of TUNEL positive cells in pshRNApten group compared to that in PshGFP group (P0.05).Conclusion PTEN down-regulation can effectively relieve the neuron injury induced by cerebral ischemia and reperfusion." @default.
- W2378096550 created "2016-06-24" @default.
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- W2378096550 date "2010-01-01" @default.
- W2378096550 modified "2023-09-26" @default.
- W2378096550 title "The protective effect of PTEN down-regulating on neuron injury of rats after global cerebral ischemia and reperfusion" @default.
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