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- W2378097802 abstract "【Objective】 To study the histone methylation patterns in peripheral blood mononuclear cells(PBMC) from type 2 diabetic patients.【Methods】 PBMC from 12 type 2 diabetic patients and 12 healthy controls were recruited.The global H3K4/H3K9 methylation was determined by assay kit.The differential expression of the histone methyltransferases and histone demethylases were measured by real-time polymerase chain reaction(RT-PCR).【Results】 Increased global H3K4 methylation was observed in PBMC of type 2 diabetic patients compared with controls.The mRNA level of gene SET1,SUV39H1,SUV39H2,KDM3A,KDM5B,LSD1 in patients' PBMC compared with healthy controls was 3.06,0.46,0.48,0.43,3.07,0.35 fold respectively.【Conclusion】 Histone methylation appears abnormal in PBMC of Type 2 diabetic patients." @default.
- W2378097802 created "2016-06-24" @default.
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- W2378097802 date "2011-01-01" @default.
- W2378097802 modified "2023-09-25" @default.
- W2378097802 title "Research on histone methylation in PBMC of type 2 diabetic patients" @default.
- W2378097802 hasPublicationYear "2011" @default.
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