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- W2378111268 abstract "Objective To explore the effect of simvastatin treatment on the level of cytokines and on accelerated atherogenesis in rheumatoid arthritis(RA). Methods Thirty-seven patients with RA treated with simvastatin,leflunomide and methotrexate.Other thirty-three patients with RA treated only leflunomide and methotrexate.The pro-inflammatory cytokines such as IL-6,TNF-α and MMP-3 were measured in RA sera pre-,12 weeks and 24 weeks of therapy.Results All the indexes had no differences between two groups before therapy(P0.05).IL-6,TNF-α, MMP-3 levels were related to CRP levels in RA patient sera.The levels of inflammatory cytokines of RA such as IL-6,TNF-α and MMP-3 were significantly decreased after treated with simvastatin for 24 weeks(P0.05).In contrast,the control group were slightly decreased.While the two groups had no difference in decrease after 12 weeks therapy.Conclusions Simvastatin may decrease the levels of cytokines and control active RA andis benefit to the future of RA." @default.
- W2378111268 created "2016-06-24" @default.
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- W2378111268 date "2008-01-01" @default.
- W2378111268 modified "2023-09-24" @default.
- W2378111268 title "Simvastatin therapy in rheumatoid arthritis" @default.
- W2378111268 hasPublicationYear "2008" @default.
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