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- W2378125479 abstract "Objective To investigate the protective effect of glycine on acute lung injury(ALI) induced by oleic acid in rats.Methods Male Wistar rats were divided randomly into 3 groups: control, ALI, ALI treated immediately after ALI induction with intravenous glycine(0.8g/kg). Lung index, glutathione (GSH) and myeloperoxidase (MPO) in pulmonary homogenate were determined 6 hours after ALI induction. Lung macrophages were isolated and cultured 6 hours after ALI induction. The IL-10 and TNFα levels in supernatants were detected by sandwich enzyme-linked immunosorbent assay and liquid phase radioimmunoassay, respectively. Pulmonary pathologic changes were compared among the three groups.Results Glycine treatment did not increase pulmonary GSH contents but decreased significantly in ALI group. Glycine treatment decreased lung index and pulmonary MPO activity and significantly ameliorated pulmonary pathologic severity.Glycine increased IL-10 but decreased TNFα,compared with ALI group.Conclusions Although glycine is not capable of accelerating GSH synthesis, prophylactic glycine may be effective in improving acute lung injury induced by oleic acid, probably through inhibition of the infiltration and activation of leukocytes." @default.
- W2378125479 created "2016-06-24" @default.
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- W2378125479 date "2004-01-01" @default.
- W2378125479 modified "2023-09-25" @default.
- W2378125479 title "Protective Effect of Glycine on Acute Lung Injury Induced by Oleic Acid in Rats" @default.
- W2378125479 hasPublicationYear "2004" @default.
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