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• W2378159605 abstract "Objective To investigate the effect of down- regulation of Capthesin L on the invasion and migration of cervical cancer cells Hela. Methods The shRNA targeting Capthesin L was designed and synthesized,and subsequently transfected into the Hela cells via Lipofectamine 2000 mediation. The migration ability and invasion ability of Hela cells were detected using transwell assay. Expression of E- cadherin,N- cadherin,WNT- 5a and Snail was assessed by using Western blot. Results Capthesin L- targeted shRNA could down- regulate the Capthesin L expression in Hela cells. Compared with control group,cell migration ability and invasion ability were significantly inhibited in shRNA interference group( P 0. 001). In addition,the expression of E- cadherin was increased,while N- cadherin,WNT- 5a and Snail were reduced in shRNA interference group. Conclusion Down- regulation of Capthesin L gene can induce inhibition of invasion and migration in cervical cancer Hela cells via regulating epithelial mesenchymal transitions( EMT).It could be regarded as a novel target for clinical diagnosis and gene therapy for cervical cancer." @default.
• W2378159605 created "2016-06-24" @default.
• W2378159605 creator A5075609240 @default.
• W2378159605 date "2014-01-01" @default.
• W2378159605 modified "2023-09-27" @default.
• W2378159605 title "Down- regulating Cathepsin L suppresses invasion and migration of human cervical cancer cell line Hela via inhibiting EMT" @default.
• W2378159605 hasPublicationYear "2014" @default.
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