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- W2378171698 abstract "【Objective】 The objective of this study was to identify whether 17beta-estradiol regulates the expression of cCyclinA2 mRNA via the estrogen receptor beta(ERbetβa) and the cAMP-PKA-extracellular signal-regulated kinase(ERK1/2) pathway.【Method】Cultured immature boar sertoli cells were treated with 10-9 mol?L-1 17beta-estradiol,and real-time PCR was used to detect the expression of cyclinA2 mRNA.【Result】Treatment with 17beta-estradiol increased the expression of cyclinA2 mRNA from 15 min to 90 min(P0.05).The effects of 17beta-estradiol activity peaked at 30 min compared to the control cells(P0.05).Combined treatment with ICI182780 and ERβ reduced the 17beta-estradiol-induced increase in the expression of cyclinA2 mRNA(P0.05),but ERβ alone did not significantly affect these parameters(P0.05).Both 17beta-estradiol and forskolin induced the abundance of cyclinA2 mRNA(P0.05 for both).Combined treatment with Rp-cAMP,H-89 and U0126 reduced the 17beta-estradiol-induced expression of cyclinA2 mRNA(P0.05 for all),but Rp-cAMP,H-89 and U0126 alone had no significant effect on the abundance of cyclinA2 mRNA,compared to the control group.【Conclusion】 This study showed that 17beta-estradiol regulates the expression of cyclinA2 mRNA via the activation of ERβ,cAMP-PKA and ERK1/2." @default.
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- W2378171698 date "2011-01-01" @default.
- W2378171698 modified "2023-09-28" @default.
- W2378171698 title "17beta-Estradiol Regulates the Expression of CyclinA2 mRNA of Cultured Immature Boar Sertoli Cells via Estrogen Receptor beta,cAMP-PKA and ERK1/2" @default.
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