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- W2378185095 abstract "Objective To study the effect of tretinoin on cellular proliferation and differentiation with human osteogenic sarcoma(HOS) cell.Methods HOS cell line was treated with various concentrations of tretinoin in different durations in vitro.Proliferation suppression was observed by MTT method and invert microscope before and after tretinoin treatment,and protracting cell growth curve.The cell growth and invasion ability was measured with the colony-formation rate in soft agar test.Flow cytometry(FCM) was used to investigate the cell cycle.Results Tretinoin significantly inhibited the proliferation of the human osteogenic sarcoma cell in a dose-dependent and time-dependent manner,and the cell underwent morphological differentiation of benign.The colony-formation rate in semi-solid agar was decreased significantly(P0.01).Tretinoin delayed cell cycle G1～S progression and induced a G1 cell cycle arrest.Determination of cell cycle showed that:the cells of the control group without inducer in a period G0/G1 ratio of 31.19%;after treating by tretinoin,the ratio of the G0/G1 phase rose to 57.94%.Conclusions Tretinoin can inhibit the proliferation of osteogenic sarcoma cell and lead to benign differentiation." @default.
- W2378185095 created "2016-06-24" @default.
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- W2378185095 date "2009-01-01" @default.
- W2378185095 modified "2023-09-27" @default.
- W2378185095 title "Tretinoin inhibits proliferation and induces differentiation of human osteogenic sarcoma cells" @default.
- W2378185095 hasPublicationYear "2009" @default.
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