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- W2378186156 abstract "Objective To study the protective effect of(-)clausenamide on the damage of PC12 cells induced by serum deprivation and to explore its related mechanism. Methods The cell viability was detected by MTT assay and morphological observation. The effect of(-)clausenamide on the PC12 cell apoptosis was analyzed by flow cytometry. Then western blotting and confocal microscope was used for the further study of effect of(-)clausenamide on the protein expression of GSK-3β,Bax and Bcl-2. Results(-)Clausenamide remarkably increased PC12 cell survival rate through inhibiting the PC12 cell apoptosis induced by serum deprivation at the concentration of 1 or 10 μ mol/L(P 0.05 or P 0.01). Meanwhile,(-)Clausenamide increased the expression of Bcl-2,and blocked the expression of GSK-3β and Bax. Conclusion(-)Clausenamide can improve the learning and memory dysfunction probably by inhibiting the neuronal damage." @default.
- W2378186156 created "2016-06-24" @default.
- W2378186156 creator A5087364900 @default.
- W2378186156 date "2009-01-01" @default.
- W2378186156 modified "2023-09-26" @default.
- W2378186156 title "Inhibitory Effect of (-)Clausenamide on Apoptosis of PC12 Cells Induced by Serum Deprivation and Its Related Mechanism" @default.
- W2378186156 hasPublicationYear "2009" @default.
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