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- W2378189740 abstract "Objective To evaluate the efficacy and safety of EPO coupled with acute normovolemic hemodilution (ANH) to avoid allogenetic blood transfusion. Methods Sixteen dogs were randomly assigned to two groups, ANH group and rhuEPO plus ANH group (preoperative subcutaneous administration of 500 IU/kg rhuEPO at 15, 11, 8,4, 0 d before surgery followed by ANH in the operating room). All dogs underwent 3 step ANH, each step 15 mL/kg blood were removed from the dog, and replaced with equal volume of dextran 40. Results On the day of surgery hematocrit increased to 0.63 in EPO group (P0.05). After 3 steps ANH, the rhuEPO coupled with ANH group had significantly higher level of hematocrit and arterial oxygen content compared with the other group. CO increased in the two groups, but in the control group the increasing of CO was insufficient to offset the decrease of oxygen content, so we can see an increase in EO 2. Conclusion The oxygen delivery is much better in the EPO coupled with ANH group than in the other group, and it is safe for futher hemodilution." @default.
- W2378189740 created "2016-06-24" @default.
- W2378189740 creator A5061490157 @default.
- W2378189740 date "2004-01-01" @default.
- W2378189740 modified "2023-09-26" @default.
- W2378189740 title "Effects of preoperative rhuEPO therapy coupled with acute normovolemic hemodilution on oxygen balance in anesthetized dogs" @default.
- W2378189740 hasPublicationYear "2004" @default.
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