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- W2378195108 abstract "Objective:To observe the effect of splenectomy on endotoxinmediated cytokine formation and the effect of pentoxifylline (PTX) in asplenic rats.Methods:128 male Wistar rats were randomly divided into three groups as follows.Control group included omentectomy and mobilization of the spleen,and it was further divided into 10 minutes and 0 5,1 5,4,12,24 hours subgroups after endotoxin administration.Splenectomy group was also subdivided into 10 minutes and 0 5,1 5,4,12,24 hours subgroups after endotoxin challenge.PTX treatment group,in which animals had undergone splenectomy,was again subdivided into 1 5 and 4 hours groups after endotoxin administration.Results:Plasma tumor necrosis factorα(TNFα) levels increased markedly in splenectomy group following endotoxin administration.However,plasma interleukin6(IL6) levels significantly decreased in splenectomy group.Treatment with PTX could significantly reduce plasma TNFα levels,but PTX had no marked effect on plasma IL6 levels.Conclusions:Splenectomy can modify cytokine formation,it is surmised that inflammatory mediators may play an important role in the development of overwhelming postsplenectomy infection (OPSI).Treatment with PTX can effectively block excessive TNFα release in splenectomized rats,suggesting that PTX would be a promising new agent in the treatment of OPSI." @default.
- W2378195108 created "2016-06-24" @default.
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- W2378195108 date "1999-01-01" @default.
- W2378195108 modified "2023-09-23" @default.
- W2378195108 title "Effect of splenectomy on endotoxinmediated tumor necrosis factorα and interleukin6 formation in rats" @default.
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