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- W2378204962 abstract "Objective:To explore the association between polymorphism of the methylenetetrahydrofolate reductase gene(MTHFR C677T),Factor V gene(FV G1691A)and prothrombin gene(FII G20210A)with recurrent spontaneous abortion in Gansu province. Methods:one hundred and two women with recurrent spontaneous abortion and one hundred controls were genotyped for MTHFR gene,FV gene and FII gene polymorphisms by sequencing technique.Results:MTHFR gene T/T genotype were increased in RSA(41.2%)versus controls(26%)and the risk ratio was 3.12(95% CI,1.36-7.13,P=0.005);MTHFR gene T allele frequencies were increased in RSA(57.8.2%)versus controls(43.5%)and the risk ratio was 2.55(95% CI,0.99-2.40,P0.01). There was significant difference between the two groups with genotype of MTHFR C677 T gene. However,FV G1691 A and FII G20210 A mutation were not found either in RSA or in controls. Conclusion:MTHFR gene C677 T polymorphism may be one of the genetic risk factors of RSA in Gansu province. FV G1691 A and FII G20210 A gene mutation may be have a lower incidence of RSA in Gansu province." @default.
- W2378204962 created "2016-06-24" @default.
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- W2378204962 date "2015-01-01" @default.
- W2378204962 modified "2023-10-11" @default.
- W2378204962 title "The association between three inheritable thrombophilia genes mutation and recurrent spontaneous abortion in Gansu province" @default.
- W2378204962 hasPublicationYear "2015" @default.
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