Matches in SemOpenAlex for { <https://semopenalex.org/work/W2378208976> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2378208976 abstract "Objective: To explore the effect of sodium butyrate on the cell apoptosis of human pancreatic cancer cell line BxPC-3 and its mechanism.Methods: The proliferating activity of BxPC-3 cells was observed by MTT assay.Flowcytometry was used to assess the apoptosis after sodium butyrate treatment.And TRAP-ELISA was applied to analyze the telomerase activity of human pancreatic cancer cell.In addition,the expressions of telomerase hTERT mRNA and Bcl-2 mRNA were confirmed by RT-PCR technology.Results: A time and dose dependent inhibition was remarkably confirmed in BxPC-3 cells.As compared with that in control group,apoptosis rate of BxPC-3 cells in sodium butyrate group was increased obviously at 72 h(P0.01).The percentage of S phase decreased significantly,while the percentage of G0/G1 phase increased markedly(both P0.05).The activity of telomerase in research group was significantly lower than that in control group(0.96±0.12 vs 4.18±0.34,P0.05).Furthermore,the expression level of hTERT mRNA and bcl-2 mRNA in sodium butyrate group was significantly lower(0.168±0.045 vs 0.685±0.141,0.138±0.034 vs 0.715±0.026,respectively,both P0.01).Conclusion: Sodium butyrate can greatly induce apoptosis ofpancreatic cancer BxPC-3 cell line,and the decline of expression level of hTERT Bcl-2 mRNA might contribute to the procedure of apoptosis." @default.
- W2378208976 created "2016-06-24" @default.
- W2378208976 creator A5005478053 @default.
- W2378208976 date "2008-01-01" @default.
- W2378208976 modified "2023-09-28" @default.
- W2378208976 title "Effects of Sodium Butyrate on the Apoptosis of Human Pancreatic Cancer Cell Line BxPC-3" @default.
- W2378208976 hasPublicationYear "2008" @default.
- W2378208976 type Work @default.
- W2378208976 sameAs 2378208976 @default.
- W2378208976 citedByCount "0" @default.
- W2378208976 crossrefType "journal-article" @default.
- W2378208976 hasAuthorship W2378208976A5005478053 @default.
- W2378208976 hasConcept C100544194 @default.
- W2378208976 hasConcept C104317684 @default.
- W2378208976 hasConcept C105580179 @default.
- W2378208976 hasConcept C121608353 @default.
- W2378208976 hasConcept C125593758 @default.
- W2378208976 hasConcept C126322002 @default.
- W2378208976 hasConcept C134018914 @default.
- W2378208976 hasConcept C153911025 @default.
- W2378208976 hasConcept C185592680 @default.
- W2378208976 hasConcept C190283241 @default.
- W2378208976 hasConcept C2776979534 @default.
- W2378208976 hasConcept C2778942008 @default.
- W2378208976 hasConcept C2780210213 @default.
- W2378208976 hasConcept C2780783641 @default.
- W2378208976 hasConcept C502942594 @default.
- W2378208976 hasConcept C54355233 @default.
- W2378208976 hasConcept C55493867 @default.
- W2378208976 hasConcept C71924100 @default.
- W2378208976 hasConcept C81885089 @default.
- W2378208976 hasConcept C86803240 @default.
- W2378208976 hasConcept C94581717 @default.
- W2378208976 hasConceptScore W2378208976C100544194 @default.
- W2378208976 hasConceptScore W2378208976C104317684 @default.
- W2378208976 hasConceptScore W2378208976C105580179 @default.
- W2378208976 hasConceptScore W2378208976C121608353 @default.
- W2378208976 hasConceptScore W2378208976C125593758 @default.
- W2378208976 hasConceptScore W2378208976C126322002 @default.
- W2378208976 hasConceptScore W2378208976C134018914 @default.
- W2378208976 hasConceptScore W2378208976C153911025 @default.
- W2378208976 hasConceptScore W2378208976C185592680 @default.
- W2378208976 hasConceptScore W2378208976C190283241 @default.
- W2378208976 hasConceptScore W2378208976C2776979534 @default.
- W2378208976 hasConceptScore W2378208976C2778942008 @default.
- W2378208976 hasConceptScore W2378208976C2780210213 @default.
- W2378208976 hasConceptScore W2378208976C2780783641 @default.
- W2378208976 hasConceptScore W2378208976C502942594 @default.
- W2378208976 hasConceptScore W2378208976C54355233 @default.
- W2378208976 hasConceptScore W2378208976C55493867 @default.
- W2378208976 hasConceptScore W2378208976C71924100 @default.
- W2378208976 hasConceptScore W2378208976C81885089 @default.
- W2378208976 hasConceptScore W2378208976C86803240 @default.
- W2378208976 hasConceptScore W2378208976C94581717 @default.
- W2378208976 hasLocation W23782089761 @default.
- W2378208976 hasOpenAccess W2378208976 @default.
- W2378208976 hasPrimaryLocation W23782089761 @default.
- W2378208976 hasRelatedWork W2351418252 @default.
- W2378208976 hasRelatedWork W2356448472 @default.
- W2378208976 hasRelatedWork W2368853760 @default.
- W2378208976 hasRelatedWork W2375562169 @default.
- W2378208976 hasRelatedWork W2378388274 @default.
- W2378208976 hasRelatedWork W2378636530 @default.
- W2378208976 hasRelatedWork W2383206229 @default.
- W2378208976 hasRelatedWork W2383460126 @default.
- W2378208976 hasRelatedWork W2390801620 @default.
- W2378208976 hasRelatedWork W2391100451 @default.
- W2378208976 hasRelatedWork W2404621657 @default.
- W2378208976 hasRelatedWork W2588602669 @default.
- W2378208976 hasRelatedWork W3028833199 @default.
- W2378208976 hasRelatedWork W3029731479 @default.
- W2378208976 hasRelatedWork W3029744252 @default.
- W2378208976 hasRelatedWork W3030826933 @default.
- W2378208976 hasRelatedWork W3031642142 @default.
- W2378208976 hasRelatedWork W3032500323 @default.
- W2378208976 hasRelatedWork W3032676355 @default.
- W2378208976 hasRelatedWork W3130963566 @default.
- W2378208976 isParatext "false" @default.
- W2378208976 isRetracted "false" @default.
- W2378208976 magId "2378208976" @default.
- W2378208976 workType "article" @default.