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- W2378226527 abstract "Objective In order to examine the mechanism of heart-protectin musk pill (HMP) in increasing blood perfusion of the ischemic myocardium .Methods We studied the effect of HMP on nitric oxide (NO) metabolism of arterial wall in cholesteriol-fed rabbits .The level of endothelial nitric oxide synthase (eNOS) mRNA was detected by quantitative reverse transcription polymerase chain reaction(RT-PCR). Nitric oxide synthase (NOS)activity of arterial wall and the concentration of plasma nitric oxide production (NOP) were measured in three groups (Control group (C)n=8,Hypercholesterolemia group(HC)n=8 and HMP group (SX)n=9).Results Indicate that hyperlipidemia caused decrease in eNOS mRNA levels and NOS activity (compared with C group, P 0 05) It reduced the quantity of NOP simutanuoesly (compared with C group , P 0 05) HMP can partly reverse the impairement of NO system .It had a tendency of increasing eNOS mRNA levels (compared with HC group, 0.1 P 0 05)and markedly elevated the NOS activity and the concentration of NOP (compared with HC group, P 0.05).Conclusion This observation supports the hypothesis that the effect of increasing myocardium perfusion of HMP may be related to improve NO metabolism. [" @default.
- W2378226527 created "2016-06-24" @default.
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- W2378226527 date "1999-01-01" @default.
- W2378226527 modified "2023-09-23" @default.
- W2378226527 title "Effect of heart-protecting musk pill on nitric oxide metabolism of arterial wall in cholesteriol-fed rabbits" @default.
- W2378226527 hasPublicationYear "1999" @default.
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