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- W2378294214 abstract "Objective To investigate the effects and its potential mechanisms of trametesrobiniophila murr granules on survival time of mouse heart grafts.Methods After the mouse heart transplantation,intragastric administration was done on the recipients with Chinese medicine extractum of trametes robiniophila murr(6mg/g).The control groups of allotransplantation and syngenic transplantation were treated by intragastric administration of purified water.The donor's heart was harvested at 5th day after operation or at the end of the graft rejection and embedded by paraffin,and cut into sections stained with hematoxylin and eosin and immunofluorescence.Results The average survival time of the grafts was 8.0±0.53 days in the allotransplantation group and 6.0±0.26 days in the group of rametes robiniophila murr granules,respectively,with the difference being statistically significant(P0.001).There were degenerations and necrosis,infiltration of CD8+ T cells and expression of Fas ligand in cardiac muscle tissues in these two groups.But the syngenic transplantation group differed in all above aspects contrast to the two groups.Conclusion During mouse heart transplantation,the survival time of grafts is shortened by intragastric administration of Chinese medicine extractum of trametes robiniophila murr,which was probably related to the enhanced infiltration of CD8+ T cells and expression of Fas ligand." @default.
- W2378294214 created "2016-06-24" @default.
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- W2378294214 date "2008-01-01" @default.
- W2378294214 modified "2023-09-27" @default.
- W2378294214 title "Effects of rametes robiniophila murr granules on survival time of mouse heart grafts" @default.
- W2378294214 hasPublicationYear "2008" @default.
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