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- W2378297530 abstract "Objective To evaluate the effects of perfluorocarbon(PFC) intraperitoneal injection on tumor necrosis factor-alpha(TNF-α)levels in rats with acute lung injury(ALI).Methods Sixty Wistar rats were divided into normal control-group,LPS-group and PFC-group.PFC-group rats were treated with intraperitoneal injection of C8F18 15 ml·kg~(-1) at 48 h before the time of injury,then LPSgroup and PFC-group were injected with 7 ml·kg~(-1)LPS.Pathological grade,TNF-αlevel in serum and BALF at 2 h,4 h and 6 h were assessed respectively.Results The level of TNF-αin BALF in PFC-group at 6 h was lower than LPS-group(9.60±0.61 pg·ml~(-1) vs 10.75±1.09 pg·ml~(-1),P0.05).There was no difference of pathological grade between two groups.Conclusion The intraperitoneal injection of PFC can reduce levels of TNF-αin lung,which may attenuate inflammation of ALI rat." @default.
- W2378297530 created "2016-06-24" @default.
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- W2378297530 date "2006-01-01" @default.
- W2378297530 modified "2023-09-23" @default.
- W2378297530 title "Effects of perfluorocarbon intraperitoneal injection on tumor necrosis factor-alpha levels in rats with acute lung injury" @default.
- W2378297530 hasPublicationYear "2006" @default.
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