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- W2378348052 abstract "Objective:To investigate the protective effect of glycyrrhizin on renal function and its possible mechanisms in rats with diabetic nephropathy(DN).Methods:Thirty male Wistar rats were randomly divided into normal group,model group and glycyrrhizin group.Diabetes was induced by intraperitoneal injection of streptozotocin(60mg/kg).Glycyrrhizin was given to rats in glycyrrhizin group for 16 weeks(30mg/kg/d).The urinary protein 24-hour(UP24),kidney hypertrophy(kidney weight/body weight),superoxide dismutase(SOD)activity,malondialdehyde(MDA)content in serum,aldose reductase(AR)activity and ARmRNA expression in kidney were measured after the treatment.Results:UP24,kidney hypertrophy,serum MDA content,kidney AR activity and its expression significantly increased,while serum SOD decreased in model group compared with normal group(P0.01).After treatment of glycyrrhizin for 16 weeks,UP24,kidney hypertrophy,serum MDA content,kidney AR activity and its expression markedly decreased(P0.01)and serum SOD activity increased(P0.05)compared with model group.Conclusion:Hyperglycemia can promote the development of diabetic nephropathy by inducing oxidative stress,polyol pathway activation and their synergy effects.Traditional Chinese medicine glycyrrhizin could ameliorate renal dysfunction through reduction of oxidative stress and polyol pathway." @default.
- W2378348052 created "2016-06-24" @default.
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- W2378348052 date "2012-01-01" @default.
- W2378348052 modified "2023-09-26" @default.
- W2378348052 title "Effects of glycyrrhizin on oxidative stress and aldose reductase in rats with diabetic nephropathy" @default.
- W2378348052 hasPublicationYear "2012" @default.
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