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- W2378354159 abstract ":Objective:Rhizoma polygoni cuspidati is a chinese medicinal herb with large antiviral range, in order to understand and exploit it's antiviral properties, the authors extracted anthraquinones of it, that is cryatalline Ⅰ and crystalline Ⅳ, and observed effects of anticoxsackie B 3 virus of them. Methods:Used ribavirin as positive control, and by way of plaque reduction assays, carry out this research. Results:In HEP 2 cell system, the ED 50 s of direct virucidal activity, the inhibition effects on the multiplication and infection of coxsackie B 3 virus are 6.26μg/mL, 7.50μg/mL, 1.75μg/mL respectively, the corresponding figures of crystalline Ⅰ are 1.54μg/mL, 8.34μg/mL, 3.06μg/mL separately, and the corresponding figures of crystalline Ⅳ are 1.79μg/mL, 7.05μg/mL, 3.17μg/mL repectively. Conclusion:The treatedment indices (TI) of crystalline Ⅰ to CVB 3 are 4.7, 1.0, 2.9 times of ribavirin TIs, the TIs of crystalline Ⅳ to CVB 3 are 27.5, 8.4, 18.8 times of ribavirin TIs, they should be worth exploitation." @default.
- W2378354159 created "2016-06-24" @default.
- W2378354159 creator A5046137843 @default.
- W2378354159 date "1999-01-01" @default.
- W2378354159 modified "2023-09-25" @default.
- W2378354159 title "Experimental Research on Effects of Anticoxsackie B 3 Virus of Anthraquinones of Rhizoma Polygoni Cuspidati" @default.
- W2378354159 hasPublicationYear "1999" @default.
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