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- W2378371535 abstract "DNA methyltransferase(DNMT) inhibitors,a prototype of epigenetic regulation,exert the therapeutic action on acute myeloid leukemia(AML)and myelodysplastic syndrome(MDS). Due to the limited efficacy of monotherapy of DNMT inhibitors in AML and MDS,numerous clinical trials of DNMT inhibitor-based combination modality therapies are under research. Some clinical trials indicate that DNMT inhibitors combined with either targeted drugs like histone acetylation enzyme inhibitors or immune regulator drugs like lenalidomide are superior to the monotherapy of DNMT inhibitors.In recent years,DNMT inhibitors combined with traditional chemotherapy for high-risk MDS and AML have shown some effects.However,DNMT inhibitor-based combination modality therapies for high-risk MDS and refractory AML still need researching." @default.
- W2378371535 created "2016-06-24" @default.
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- W2378371535 date "2015-01-01" @default.
- W2378371535 modified "2023-09-26" @default.
- W2378371535 title "Progress in combined treatments of myelodysplastic syndrome and acute myeloid leukemia based on DNA methyltransferase inhibitors" @default.
- W2378371535 hasPublicationYear "2015" @default.
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