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- W2378432359 abstract "Objective To explore the effect of ligustrazine on Nrf2/ARE pathway in liver tissue of hepatic fibrosis rats induced by CCl4 for studying the mechanism of its effect on hepatic fibrosis. Methods Hepatic fibrosis in rats was induced by carbon tetrachloride, rats were randomly divided into normal control group, hepatic fibrosis group and treatment group. treatment group rats were given ligustrazine intraperitoneally everyday while inducing hepatic fibrosis by carbon tetrachloride. After 6 weeks, rats were killed for collecting blood and liver tissues. Endotoxin in blood plasma was measured with a limulus amebocyte lysate test kit. The pathological changes of liver were observed by hematoxylin-eosin staining, the degree of liver fibrosis was assessed by stained of Sirius red for collgen and the contents of hydroxyproline in liver tissues. Nrf2 protein expression in liver tissues was detected by West-blotting method. The contents of malondialdehyde(MDA) in liver tissues were determined by TBA method, glutathione S-transferase(GST) by colorimetric enzymatic assay. Results Fibrotic changes in liver of treatment group were ameliorated significantly compared with the hepatic fibrosis model group, and the content of plasma endotoxin were reduced, liver expression of Nrf2 was increased as well as GST, MDA was reduced accordingly. Conclusion The protective effect of ligustrazine on liver fibrosis is possibly related to reducing endotoximia and activating Nrf2/ARE pathway in liver, thus increasing the content of antioxidant enzymes such as GST." @default.
- W2378432359 created "2016-06-24" @default.
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- W2378432359 date "2014-01-01" @default.
- W2378432359 modified "2023-09-27" @default.
- W2378432359 title "Effect of ligustrazine on Nrf2/ARE pathway in liver tissue of hepatic fibrosis rats induced by CCl_4" @default.
- W2378432359 hasPublicationYear "2014" @default.
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