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- W2378471010 abstract "Objective To evaluate the changes and clinical significance of serum endotxin and growth hormone (GH)/GH binding protein (GHBP) in patient with obstructive jaundice (OJ).Methods Serum level of GH,GHBP,insulin like growth factor Ⅰ(IGF Ⅰ),endotoxin,prealbumin and liver function in 60 male inpatients with OJ were investigated 1 day preoperation and 1,7 days postoperation respectively,and 40 male synchronization patients with simple gallbladder stone were chosen as control group.Results The levels of GH,GHBP and IGF I in the patients with OJ [(7.4±3.6)?μg/L,(9.1±2.3)?B/T×100,(49.8±6.6)?mg/L,respectively] were significantly lower than those in the control group [(13.9± 5.7)?μg/L,(13.3±1.6)?B/T×100,(61.4±6.5)?mg/L,respectively (P0.01)] and were correlated well with the levels of bilirubin,endotoxin and prealbumin (P0.01).Conclusion GH/GHBP axis was obviously down regulated in the patients with OJ probably because of the expression inhibition resulting from nutrition dysfunction and endotoxemia.It may be one of the important factors intervening the changes of pathophysiology in OJ." @default.
- W2378471010 created "2016-06-24" @default.
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- W2378471010 date "2002-01-01" @default.
- W2378471010 modified "2023-09-28" @default.
- W2378471010 title "Study on the correlation between serum endotoxin and growth hormore (GH),GH binding protein in patient with obstructive jaundice" @default.
- W2378471010 hasPublicationYear "2002" @default.
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