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- W2378478412 abstract "Objective To select chemotherapeutic agents for guiding tailor-made chemotherapy by chemosensitivity test of glioma cells in tissue culture.Methods Sixty-nine specimens of brain glioma were used to evaluate the chemosensitivity of glioma cells by tissue culture in vitro.The chemotherapeutic agents tested for brain cancer were cisplatin(DDP),vincristine(VCR),teniposide(VM26),nimustine(ACNU),temozolomide(TMZ) and DDP+VM26 group.The antineoplastic effects of these agents were compared,and the correlations between the chemosensitivity and patient characteristics were analyzed.Results There was no significant difference in the chemosensitivity between of DDP+VM26 and VM26 alone,but both of them were significantly higher than the other four groups.There was no significant influence of patients' sex and age and oncogenesis or relapse of the tumors on chemosensitivity.Except DDP+VM26 group,the other drugs showed no significant correlation of chemosensitivity with the pathological grade of the tumor.Conclusion In vitro chemosensitivity of glioma varies with not only the individuals but also the chemotherapeutic agents,and combined agents containing VM26 are more effective for glioma treatment." @default.
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- W2378478412 date "2007-01-01" @default.
- W2378478412 modified "2023-09-25" @default.
- W2378478412 title "In vitro chemosensitivity test of glioma cells in tissue culture" @default.
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