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- W2378486032 abstract "Objective To elucidate the effect of DNA vaccine against neurite growth inhibitors, pcDNA3.1(+) neurite inhibitors (pcDNA-NGIs) on neurite regeneration following focal cerebral ischemia. Methods The left focal cerebral ischemia was permanently induced by the occlusion of the left middle cerebral arteries in 72 rats. pcDNA-NGIs was injected into the tibial muscle once a week for 6 weeks before or after the stroke. The newly generated axons of corticorubral projection were traced by stereotaxic guided injection of biotinylated dextran amine 6 weeks after the presentation of the specific antibodies in the serum. Results pcDNA-NGIs administrated before or after the stroke led to increase in compensatory new growth of axons of corticorubral projection following the focal cerebral ischemia. Conclusion It is suggested that pcDNA-NGIs administrated before or after the stroke is beneficial to neurite regeneration following the permanent local cerebral ischemia." @default.
- W2378486032 created "2016-06-24" @default.
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- W2378486032 date "2008-01-01" @default.
- W2378486032 modified "2023-09-25" @default.
- W2378486032 title "Effect of DNA Vaccine against Neurite Growth Inhibitors on Neural Regeneration Following Focal Cerebral Ischemia in Rats" @default.
- W2378486032 hasPublicationYear "2008" @default.
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