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- W2378508744 abstract "Objective To observe the changes of Fas/Fas L levels of peripheral blood T lymphocytes and synovial membrane in rats with adjuvant arthritis before and after treatment with leflunomide,so as to understand the effects of leflunomide on the apoptosis of peripheral blood T lymphocytes and synovial cells.Methods Sixty Wistar rats were divided into five groups randomly: control group,model group,leflunomide treatment group(LEF group),methotrexate group(MTX) and MTX+LEF group.The arthritis index,levels of serum Fas/Fas L in various groups were observed,the expression of Fas/Fas L in synovial tissue was detected by immunohistochemistry.Results On the 60th day,arthritis index in each experimental group decreased,MTX group6.83±1.93 vs 3.38±1.61(P0.01);LEF group 7.35±2.16 vs 3.25±1.17(P0.01);MTX+LEF group 7.21±1.82 vs 2.13±1.18(P0.01),no change in model group,7.12±1.67 vs 6.25±1.46(P0.05).The levels of serum Fas and Fas L decreased in all experimental groups,Fas,MTX group(55.3±7.5)% vs(27.3±6.8)%(P0.01);LEF group(58.3±8.1)% vs(25.9±7.2)%(P0.01);MTX+LEF group(54.6±7.4)% vs(18.2±4.9)%(P0.01);Fas L,MTX group(4.1±0.5)% vs(2.4±0.5)%(P0.01);LEF group(3.7±0.6)% vs(2.5±0.4)%(P0.01);MTX+LEF group(3.8±0.6)% vs(1.7±0.4)%(P0.01),but no change in model group,Fas(57.1±7.9)% vs(64.2±8.4)%(P0.05);Fas L(4.0±0.7)% vs(4.1±0.6)%(P0.05).Compared with control group,the expression of Fas protein in synovial tissue increased in model group and each experimental groups,MTX group(7.5±2.2) scores vs(4.2±1.0) scores(P0.01);LEF group(7.7±2.1) scores vs(4.2±1.0) scores(P0.01);MTX+LEF group(9.4±2.1) scores vs(4.2±1.0) scores(P0.01);model group(5.6±1.9) scores vs(4.2±1.0) scores(P0.01).The expression of Fas L protein increased in the experimental groups,MTX group(7.8±2.1) scores vs(5.2±1.0) scores(P0.01);LEF group(7.9±1.8) scores vs(5.2±1.0) scores(P0.01);MTX+LEF group(9.4±1.8) scores vs(5.2±1.0) scores(P0.01),decreased in model group,(2.0±0.9) scores vs(5.2±1.0) scores(P0.01).Conclusion Leflunomide can reduce the expression of Fas system in peripheral blood T lymphocytes and synovial membrane of rats with AA to achieve the effect of anti-rheumatic." @default.
- W2378508744 created "2016-06-24" @default.
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- W2378508744 date "2011-01-01" @default.
- W2378508744 modified "2023-09-25" @default.
- W2378508744 title "Effect of leflunomide on Fas system in serum and synovial of rats with adjuvant arthritis" @default.
- W2378508744 hasPublicationYear "2011" @default.
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