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- W2378517800 abstract "OBJECTIVE To study the part of the relevant mechanisms of losartan on hepatic fibrosis of mice infected with Schistosoma japonicum.METHODS Thirty-six kunming mice were randomly divided into three groups: the normal control group,the infectious control group and the test(losartan) group.Schistosomal liver fibrosis model was established by challenge with 35 cercariae S.japonicum.The test group was treated by losartan for 6 weeks.After 6 weeks of treatment,liver samples of the mice were obtained for observing the histopathological changes,the radioimmunoassay was used to detect the serum(HA) in hepatic fibrosis,the(SP) immunohistochemistry and image pro-plus 5.0 were applied to detect the expression of α(SMA),(TIMP)-1,and the real-time PCR was applied to detect the quantity of AT1R mRNA and transforming growth factor β1(TGFβ1) mRNA.RESULTS Compared with infectious control group,the liver histopathology was improved significantly.Losartan could significantly reduce(HA);and the levels of αSMA and TIMP-1 were degraded(P0.05).The quantity of AT1R mRNA and TGFβ1 mRNA in losartan group was lower than that in infectious control group(P0.05).CONCLUSIONS The losartan group can obviously improve liver histopathology,reduce serum HA.The possible reason is to markedly inhibit the expression of αSMA,TIMP-1,AT1R mRNA and TGFβ1 mRNA." @default.
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- W2378517800 date "2010-01-01" @default.
- W2378517800 modified "2023-10-03" @default.
- W2378517800 title "Effect of losartan on expression of AT1R mRNA and TGF-β1 mRNA in hepatic fibrosis of mice infected with Schistosoma japonicum." @default.
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