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- W2378565553 abstract "Objective： To investigate whether nanoselenium(NS) can prevent lung tumorigenesis in Kunming mice induced by tobacco specific nitrosamine 4 (methylnitrosamino) 1 (3 pyridyl) 1 butanone(NNK). Methods： The model of NNK induced lung tumorigegesis in mice was established by a single dose of 500μ mol/kg intraperitoneally. The incidence of tumor and numbersof tumor nodes in the lung were observed 8 months after NNK treatment. The immune functions, such as phagocytosis of macrophage in the abdominal cavity, plaque forming cells and delayed type hypersensitivity etc. were examined at day 1, 3, 7, 15 and 30 following NNK injection. Results： Eight months after NNK treatment, the incidence of lung tumor in mice was 93.3％ (28/30), and the overage tumor nodes were 5.075± 2.98 per lung. The tumor was adenocarcinoma ascertained by histopathological examination. The 0.5, 1.0 and 3.0 ppm of selenium in NS decreased the incidence of tumor formation to 69.2％ (18/26), 56.6％ (17/30), 46.7％ (14/30) and reduced tumor nodes to 2.29± 2.23, 1.37± 2.47, 1.09± 1.31 per lung,respectively. The dysfunction of immune system in mice were observed during one month fouoming NNK administration, and were obviously ameliorated by NS. Conclusion： The NS can inhibit NNK induced lung tumorigenesis in mice with a better dose response relationship, and the mechanism may be related to immunoregulation of selenium." @default.
- W2378565553 created "2016-06-24" @default.
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- W2378565553 date "2000-01-01" @default.
- W2378565553 modified "2023-09-25" @default.
- W2378565553 title "Nanoselenium prevents lung tumorigenesis induced by 4- (methylnitrosamino)-1-(3- pyridyl)-1-butanone in Kunming mice" @default.
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