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- W2378572302 abstract "Aim To investigate the effects and mechanisms of glucosides of chaenomeles speciosa (GCS) in mice with contact hypersensitivity (CHS) response. Methods CHS model in mice induced by 2,4-dinitro-I-dinitroflurobenzene (DNFB) was used in this study. Concanavalin A (Con A)-induced splenocytes proliferation was measured by the MTT colorimetric method and interleukin-2 (IL-2) activity was measured by testing its ability to support ConA-induced mice splenocytes proliferation by MTT method. Interleukin-4 (IL-4) and transforming growth factor -beta 1 (TGF-β 1) levels were determined by ELISA. T lymphocytes subsets were measured by flow cytometry. Results Similar as the control drug 4-acetylaminophenylacetic acid (actarit or Acta) (120 mg·kg -1), GCS (240 mg·kg -1) could inhibit the thymus index and spleen index in CHS mice. GCS( 60,120,240 mg·kg -1) could inhibit the ear swelling of CHS mice and could inhibit the splenocytes proliferation induced by ConA. GCS (240 mg·kg -1)decreased CD4 +CD8 +T lymphocytes subsets ratio and resumed the CD4 +CD8 -subsets ratio in CHS mice;GCS(240,60 mg·kg -1) resumed the CD4 -CD8 -subsets ratio in CHS mice. GCS also decreased the TGF-β 1 and IL-2 levels and increased the IL-4 levels in mice thymus with CHS. Conclusion GCS could inhibit mice CHS reaction and resume the balance of T lymphocytes subsets in mice thymus with CHS, and also could modulate the cytokines production by CD4 + T lymphocytes of CHS mice." @default.
- W2378572302 created "2016-06-24" @default.
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- W2378572302 date "2004-01-01" @default.
- W2378572302 modified "2023-09-25" @default.
- W2378572302 title "Glucosides of Chaenomeles speciosa suppressed contact hypersensitivity response via modulating the thymus T lymphocytes subsets in mice" @default.
- W2378572302 hasPublicationYear "2004" @default.
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