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- W2378573511 abstract "Objective To investigate the expression of vascular growth factors including vascular endothelial growth factor(VEGF), basic fibroblast growth factor(bFGF) and platelet-derived growth factor (p-DGF) in placentae of pregnancy-induced hypertension(PIH) patients and their significance. Methods Placental tissues of 15 normal gravidas and 19 PIH women were collected. The expression of vascular growth factors were detected by immunohistochemistry (PAP) combined with the analysis of computer microphotography. Results The average grey value difference (GVD) of VEGF was 61.6±3.7 in moderate and severe PIH group, which was significantly lower than that of the normal control group (71.1±5.8) and mild PIH (70.9±8.9, P0.01); the average GVD of bFGF in the moderate and severe PIH group (60.9±8.8) was significantly lower than that of the control group (79.7±7.6) and mild PIH group (78.4±10.4, P0.01) and the average GVD of p-DGF in the moderate and severe PIH group (37.5±5.6) was higher than that in the control group (22.1±(3.1)) and mild PIH group(21.8±4.3, P0.01). Conclusions Abnormal expression of the placental vascular growth factors might result in decreased placental blood vessel distribution, increased tension or spasm of blood vessel and lead to the pathologic and physiologic changes in PIH." @default.
- W2378573511 created "2016-06-24" @default.
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- W2378573511 date "2005-01-01" @default.
- W2378573511 modified "2023-09-25" @default.
- W2378573511 title "Expression of placental vascular growth factor in pregnancy-induced hypertension" @default.
- W2378573511 hasPublicationYear "2005" @default.
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