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- W2378588268 abstract "Objective:To investigate the antagonism of supercritical-CO2 alcohol fluid extractions of Pinellia Tuber on the mode of seizure rats induced by penicillin and explore its mechanism of anticonvulsant action.Methods:Using the model of seizure rats induced by penicillin localized injected in cortex investigated the effect of SFE-CO2 alcohol fluid extractions of Pinellia Tuber on the convulsant behaviors and hippocampus EEG(Recoded by RM6240C multichannel physiological signal collection and analysis recorder).The neurotransmitters(Glu,Asp,Gly and GABA)of hippocampus were determined by high performance liquid chromatography(HPLC).Results:SFE-CO2 alcohol fluid extractions of Pinellia Tuber could prolong the latent period on the penicillin-induced seizure and lighten the extent of seizure.At the same time,it could prolong latent period of epileptiform discharge,reduce the frequency of epileptiform discharge,decrease the highest wave of hippocampus EEG..All above observing indexes compared with the model control groups were significantly difference(P0.01).Moreover,it might have been increase the level of GABA and decrease Glu level(P0.05 or P0.01),but no statistics significant on the level of Gly,Asp(P0.05).Conclusion:SFE-CO2 alcohol fluid extractions of Pinellia Tuber could antagonize penicillin-induced seizure in rats.Its anticonvulsant properties resembled TPM.The anticonvulsant mechanism of it might have been due to increase the level of GABA and decrease Glu level." @default.
- W2378588268 created "2016-06-24" @default.
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- W2378588268 date "2009-01-01" @default.
- W2378588268 modified "2023-09-26" @default.
- W2378588268 title "The Effects of Supercritical-CO_2 Alcohol Fluid Extractions of Pinellia Tuber on the Epileptiform Discharge and Related Neurotransmitters in Hippocampus in Seizure Rats Induced by Penicillin Localized Injected in Cortex" @default.
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