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- W2378592242 abstract "Objective To compare the efficacy and toxicity and long-term survial of concurent or sequential Pemetrexed and Nedaplatin combined with three-dimensional conformal radiotherapy(3D-CRT) for local advanced non-small cell lung cancer(LANSCLC).Methods 54 patients with LANSCLC were randomly divided into three groups: the concurrent chemoradiation(CCR) group(n=27),and the sequential chemoradiation(SCR) group(n=27).The two groups were all given 3D-CRT at 2Gy/f to a total dose of 70 Gy.In the CCR group,pemetrexed 500mg/m2 and nedaplatin of 80mg/m2 were given on day 1,21,and 43.In the SCR group,two chemotherapy cycles were given before radiotherapy.Results The median follow-up was 22.8 months.For the CCR group compared to the SCR group: the objective response rate(ORR) was 77.6% vs.61.8%(P0.05);the median progression-free survival(mPFS) was 12.2 months(95%CI:8.5-14.9 months)vs.9.1 months(95%CI:6.4-11.8 months)(P0.05);the 1-year survival rate was 81.5% vs.66.7%,the 2-year survival rate was 48.1% vs.40.7%,and the 3-year survival rate was 29.6% vs.22.2%(P0.05);the median survival time(MST) was 20.5(95%CI:13.7-27.3 months) months vs.17.3 months(95%CI:14.2-20.4 months)(P0.05).The major treatment related toxicities included radiation esophagitis and radiation pneumonitis.The rate of grade 1/2 radiation esophagitis was 70.3% vs.55.5%(P0.05),grade 1/2 radiation pneumonitis 62.9% vs.44.4%(P0.05).While other toxicities such as marrow suppression,nausea and vomitting,diarrhba and mucositis were mostly grade 1/2(P0.05).Conclutions Concurrent treatment with Pemetrexed and Nedaplatin combined with 3D-CRT for LANSCLC tends to have better results than sequential therapy,and the increased toxicity can be better tolerated." @default.
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- W2378592242 date "2012-01-01" @default.
- W2378592242 modified "2023-09-23" @default.
- W2378592242 title "Efficacy of Pemetrexed and Nedaplatin Combined with Three-dimensional Conformal Radiotherapy on Locally Advanced Non-small Cell Lung Cancer" @default.
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