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- W2378601965 abstract "Objective: To study the protective effect of total flavonoids of Astragalus (TFA) on the liver against large doses of paracetamol in mice. Method:After oral administration of TFA or Vitamin C 1 h prior to giving large dose of paracetamol in mice, the changes of paracetamol-induced mortality rate, serum enzyme level and liver damage degree were obsezved. Result: Paracetamol produced 80% mortality, within 24 hours of the administration of a dose of 1 000 mg·kg -1 to the mice. Pre-treatment of the animals with TFA (100 mg·kg -1 ) or Vitamin C (1 000 mg·kg -1 ) reduced the death rate to 20% and0% respectively. There was also a significant rise in the serum enzyme level of alanine transaminase (P0.001) and the area of liver necrosis (P0.001), 24 h after paracetamol (400 mg·kg -1 ) treatment. With pre-treatment with either TFA or Vitamin C, there was an obvious dose-dependent decrease in ALT levels and the area of hepatocellular necrosis. Conclusion: TFA has potential protecting effect against the paracetamol-induced hepatic damage. [" @default.
- W2378601965 created "2016-06-24" @default.
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- W2378601965 date "2001-01-01" @default.
- W2378601965 modified "2023-09-25" @default.
- W2378601965 title "Studies on Protective Effect of Total Flavonoids of Astragalus on Liver Damage Paracetamol-Inducedby" @default.
- W2378601965 hasPublicationYear "2001" @default.
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