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- W2378613193 abstract "Objective To evaluate the one point dipolar pacing effects on myocardial mechanics and left ventricular function of acute ischemic canine using ultrasonic three-dimensional(3D) speckle tracking imaging technique.Methods Ten open-chest beagles with ventricular 3D full volumetric real-time imaging in a completed cardiac cycle were acquired respectively at baseline(BASE),and during acute ischemia(ISCH),post-ischemic right ventricular apex,left ventricular apex and lateral wall one point dipolar pacing.Left ventricular pressure-time sequence curve was recorded simultaneously for achieving left ejection pressure(LVEP) and the maximal upstroke velocity of left ventricular systolic pressure(dp/dtmax).Radial 3D strain maps and radial 3D peak strain of left ventricular wall,and left ventricular end systolic volume,diastolic volume,stroke volume,ejection fraction,cardiac output of different states were extracted respectively using ultrasonic 3D speckle tracking analysis software.The radial 3D strain synchrony of left ventricular wall during different states was qualitatively observed and compared.All parameters of left ventricular function in different mechanic patterns were linearly correlated each other.At different states,the correlation test was applied respectively between the global 3D peak strain of left ventricular wall and global volumetric parameters or pressure parameters.Results ①The mechanical asynchrony of left ventricular wall during different post-ischemic ventricular pacings was worse than those at BASE and during ISCH on the radial 3D strain maps of left ventricular wall;②Compared with BASE: left ventricular global and its 16 myocardial segments radial peak 3D strain,left ventricular ejection fraction,cardiac output,left ventricular ejection pressure and the maximal upstroke velocity of left ventricular systolic pressure decreased significantly during ISCH(P0.05);③Compared with ISCH: statistic significant increase was found for the global peak radial 3D strain of left ventricular wall(P0.05),but left ventricular stroke volume and left ventricular ejection fraction did not improve in all post-ischemic pacing patterns;④No significant difference of LVESV,LVEDV,LVSV,LVEF,LVCO,LVEP and left ventricular dp/dtmax between each post-ischemic pacing patterns(P0.05) was found;⑤The statistical significant linear correlations between the global 3D peak strain of left ventricular wall and left ventricular stroke volume,and left ventricular ejection fraction,and cardiac output in different pacing patterns were found.Conclusions Using ultrasonic 3D speckle tracking technique,The left ventricular myocardial contractility of ISCH beagles was improved via one point dipolar pacing,but the mechanical asynchrony was aggrevated;therefore,ventricular one point dipolar pacing could not improve acute-ischemia-damaged left ventricular global function effectively." @default.
- W2378613193 created "2016-06-24" @default.
- W2378613193 creator A5035083368 @default.
- W2378613193 date "2010-01-01" @default.
- W2378613193 modified "2023-09-23" @default.
- W2378613193 title "The study on left ventricular function in acute ischemic canine during one point dipolar pacing using three-dimensional ultrasonic speckle tracking" @default.
- W2378613193 hasPublicationYear "2010" @default.
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