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- W2378614061 abstract "Objective To investigate the frequency of genomic instability in murine hepatocellular carcinoma cell lines Hca/A2-P (P) and Hca/163-F (F) with high and low metastatic capacities separately, and to explore its association with genesis and metastasis of hepatocellular carcinoma. Methods Forty-two microsatellite markers were randomly selected to examine the genomic instability in F and P cells by using PCR-simple sequence length polymorphism (PCR-SSLP) analysis. Results As the microsatellite gene loci of P and F cell lines in compare with that of inbred strain C3H, the P cell line showed 30 microsatellite loci parlleled to C3H, 8 loci with loss of alleles, 5 loci with extra bands, and 4 loci with ban shifting; the F cell line showed 28 loci paralleled to C3H, 12 loci with allele loss, 4 loci with extra bands, and 1 locus with band shifting. There existed obviously different alterations of allelic band between P and F cells. Conclusion These results suggest that there are genomic instability in chromosome 3, 7, 11 and 16, which may play an important role in the development and progression of HCC in mice. It is suggested that these two sub-clones derived from the same hepatic tumor in homozygous mouse held different genetic features." @default.
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- W2378614061 date "2004-01-01" @default.
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- W2378614061 title "Comparative study of genomic instability in mice hepatocellular carcinomas with low and high metastatic capacity" @default.
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