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- W2378614387 abstract "Objective To investigate the effects and mechanisms of esmolol on myocardial injury during cardiopulmonary bypass(CPB) in children with cyanotic congenital heart disease(CCHD).Methods Sixteen patients with CCHD performed intracardiac operation under direct vision with CPB were divided randomly into observed group and control group with 8 cases in each,same operation and anesthesia method were used in the two groups,the observed group was given an esmolol infusion at a dose of 3 mg/(kg·h) from the induction to the end of operation,while the control group was given ringer's solution instead.The general conditions of operation in both groups were observed,and blood sample was taken from central vein to detect the plasma concentration of MB isoenzyme of creatine kinase(CK-MB),cardiac tropinon I(cTnI) before CPB(T1),30 min after aorta clamped(T2),30 min after aorta unclamped(T3) and 24 h after the surgery(T4).The contents of adenylic acid and mitochondrial swelling degree(MSD)in auricula dextra tissue were detected at T1,T3.Results The incidence of arrythymia,the dosage of dopamine,the time stay in ICU and days of hospital stay after surgery were markedly fewer in observed group than that in control group(P0.05);the leves of CK-MB and cTnI at T3 and T4 were significantly higher than those at T1 in both groups,the contents of adenylic acidat T3 were significantly lower than that at T1 and MSD at T3 significantly higher than that at T1(all P0.01),but the leves of CK-MB and cTnI in observed group were lower at T3 and T4 than those in control group(P0.05).Conclusion During the CPB of children with CCHD,esmolol can substantially attenuate myocardial ischemia/reperfusion injury by ameliorating myocardial energy metabolism and mitochondrial function." @default.
- W2378614387 created "2016-06-24" @default.
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- W2378614387 date "2010-01-01" @default.
- W2378614387 modified "2023-09-24" @default.
- W2378614387 title "Effects of esmolol on myocardial injury and energy metabolism during cardiopulmonary bypass in children with cyanotic congenital heart disease" @default.
- W2378614387 hasPublicationYear "2010" @default.
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