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- W2378618625 abstract "Objective To analyze the association of genetic polymorphism of Glutathione S transferase (GST) M1, T1 and N acetyltransferase 1(NAT1) with genetic susceptibility to sporadic colorectal adenocarcinoma (SCRAC). Methods All subjects were Han people in Hubei province of China. Using multiple PCR and PCR RFLP, we studied the genetic polymorphism of the GSTM1, GSTT1 and NAT1 genes. Results There were no significant differences of the frequency of GSTM1 and GSTT1 null genotype between controls and SCRAC except for the differences of frequency of NAT1 *10 (27.8%∶42.3%, P 0.05), and there were no significant differences of the frequency of GSTM1 null genotype between controls and proximal or distal SCRAC, different Dukes stages, different differentiated SCRAC and the elder or younger SCRAC respectively. The frequency of GSTT1 null genotype was more common in distal SCRAC (66.2%, P 0.05), among SCRAC in Dukes C stage (80.8%, P 0.01 ) and in poorly differentiated SCRAC (77.1%, P 0.01 ) when compared with the controls (47.5%). There were no significant differences of the frequency of NAT1 *10 between proximal or distal SCRAC and controls, but the frequency of NAT1 *10 null genotype was more common in the elder SCRAC(52.7%, P 0.01), among SCRAC in Dukes C stage (53.8%, P 0.05 ) and in moderately differentiated SCRAC(54.2%, P 0.01) when compared with the controls. Conclusions The GSTT1 null genotype may influence the distal SCRAC, and most tumors are in Dukes C stage and poorly differentiated SCRAC. NAT1 *10 may also increase the risk of SCRAC, especially in the elder, and most tumors are in Dukes C stage and moderately differentiated SCRAC." @default.
- W2378618625 created "2016-06-24" @default.
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- W2378618625 date "2003-01-01" @default.
- W2378618625 modified "2023-09-25" @default.
- W2378618625 title "Relation between genetic polymorphism in xenobiotica metabolizing enzymes and risk of sporadic colorectal adenocarcinoma" @default.
- W2378618625 hasPublicationYear "2003" @default.
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