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- W2378618991 abstract "Objective: To investigate the preventive effects of methylcobal on peripheral neuropathy in diabetic rats with varied hyperglycemia within a certain duration.Methods: Eighty diabetic Sprague Dawley rats were randomly chosen,and 16 rats were selected as normal controls.In 64 rat diabetic models induced by alloxan,the rats were divided into ID-1 group and M-ID-1 group(blood sugar controlled),and ID-2 group and M-ID-2 group (blood sugar poorly controlled)(n=16 in each group).In M-ID-1 and M-ID-2 groups,the rats were intramuscularly injected with methylcobal(500 μg/kg) every day.Twelve weeks after establishment of the models,the structure of sciatic nerves was observed under light microscopy and transmission electron microscopy.The sugar metabolism was monitored before and after treatment.Results: At 12th week after onset of diabetes,methylcobal-treated diabetic rats had significantly delayed abnormalities of sciatic nerves as compared with normal control group.In M-ID-1 group(fructosamine,1.0 mmol/L),the abnormalities of sciatic nerve structure were significantly decreased(P0.05).There was no obvious difference in nerve structural abnormalities between the M-ID-2 group(fructosamine,1.2 mmol/L) and corresponding non-treatment group.Conclusion: Methylcobal has a beneficial effect on prevention of diabetic peripheral neuropathy,which is influenced by blood sugar within a certain duration." @default.
- W2378618991 created "2016-06-24" @default.
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- W2378618991 date "2007-01-01" @default.
- W2378618991 modified "2023-09-27" @default.
- W2378618991 title "The Preventive Effect of Methylcobal on Peripheral Nerve Structural Abnormalities in Diabetic Rats" @default.
- W2378618991 hasPublicationYear "2007" @default.
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