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- W2378619839 abstract "Objective To investigate significance of nuclear factor-κB expression in peripheral blood mononuclear cell(PBMCs) in dermatomyositis(DM) patients and glucocorticoid effect on NF-κB in dermatomyositis.Methods Mononuclear cells were extracted from health adult and DM patients' peripheral blood.Activity of NF-Κb was detected by EMSA in different groups.Results ①There was little expression of NF-κB on health adult peripheral blood.There was expression of NF-κB on DM patiants'peripheral blood.②Activity of NF-κB can be inhibited by glucocorticoid.③Activity of NF-Κb in recurring patients was higher than no relapsed patients before prior treatment(P0.01).Conclusion The expression of NF-κB may take part in the pathogenesis of DM;Disequilibrium of NF-κB between glucocoriticoid receptor may be one of important factors that induce inflammatory reaction and recurrences." @default.
- W2378619839 created "2016-06-24" @default.
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- W2378619839 date "2007-01-01" @default.
- W2378619839 modified "2023-09-26" @default.
- W2378619839 title "Nuclear Factor-κB Expression and Glucocorticosteroid Effect on NF-κB in Dermatomyositis" @default.
- W2378619839 hasPublicationYear "2007" @default.
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