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- W2378622637 abstract "OBJECTIVE To investigate the effect of flesh of wild apricot(FWA) on blood lipid and its liver-activity protecting and anti-artherosclerosis in hyperlipidemia mice.METHODS The hyperlipidemia model was established by orally feeding emulsion by gavage for 4 weeks in mice.Concomitantly,the experimental mice were treated with FWA of 0.2,0.3,0.4 g·kg-1 per day respectively and Xuezhikang of 0.1 g·kg-1 per day.All of the mice were sacrificed after weighing,anesthetizing and then the materials were collected.The serum contents of total cholesterol(TC),triglyceride(TG) and high density lipoprotein-cholesterol(HDL-C) were measured.Meanwhile,the liver index,low density lipoprotein-cholesterol(LDL-C) and atherosclerotic index(AI) were calculated as well.Pathological changes in liver were studied with the method of histology in order to observe whether FWA could protect liver of mice with hyperlipidemia.RESULTS FWA could significantly decrease the liver index(P0.01)and the serum contents of TC,TG,LDL-C and AI(P0.01).The serum content of HDL-C was significantly higher in FWA groups(especially in the high dose group,P0.01) than that in the model group(P0.01).Importantly,the histological evaluation of liver specimens demonstrated that the extent of steatosis in liver of FWA-treated groups was reduced.CONCLUSION FWA indeed could reduce the blood lipid in hyperlipidemia mice.To some extent,FWA could also prevent liver from steatosisin hyperlipidemia mice.Moreover,our data have revealed that FWA had potential effect on anti-artherosclerosis.In addition,the efficacy of FWA showed a certain relationship with dosage." @default.
- W2378622637 created "2016-06-24" @default.
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- W2378622637 date "2011-01-01" @default.
- W2378622637 modified "2023-09-23" @default.
- W2378622637 title "Effect of wild apricot on blood lipid and it's liver-activity protecting in hyperlipidemia mice" @default.
- W2378622637 hasPublicationYear "2011" @default.
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