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- W2378623151 abstract "Objective To investigate the effects of local applied rapamycin on the intima hyperplasia in the vein graft after coronary artery bypass grafting(CABG). Methods CABG animal models were established on 24 Yorkshire pigs by grafing the great saphenous vein between the ascending aorta and circumflex coronary artery.The animals were randomly divided into three groups(n=8): blank control group,only CABG was performed;blank carrier control group,receiving local application of 0.5 mL 20% Pluronic F-127 around the vein graft;and rapamycin group,receiving local application of 0.5 mL 20% Pluronic F-127 with 100 mg/mL rapamycin.The animals were sacrificed two months later.The extent of intima hyperplasia and degree of lumina stenosis were observed under light microscope with HE staining,the cell proliferation was observed with immunohistochemical staining,and the apoptosis was detected by TUNEL assay. ResultsCompared with blank control group and blank carrier control group,the intima hyperplasy of rapamycin group was significantly decreased,and the intima thickness was(78.85±12.63),(177.99±12.55) and(168.21±11.58)μm,respectively(P0.05).The lumina stenosis was also significantly decreased,and the 1umina area/1umina plus intima area was 0.910±0.011,0.796±0.015 and 0.798±0.015,respectively(P0.05).The cell proliferation was significantly inhibited,and the proliferation indexes were(19.0±4.6)%,(33.5±5.2)% and(36.4±5.6)%,respectively(P0.05).The cell apoptosis was significantly increased,and the apoptosis indexes were(30.3±5.4)%,(17.9±3.8)% and(19.5±4.8)%,respectively(P0.05). Conclusion Local delivery of slow-releasing rapamycin carried by Pluronic F-127 can inhibit intima hyperplasia of the vein graft effectively by inhibiting the proliferation of smooth muscle cells and promoting cell apoptosis." @default.
- W2378623151 created "2016-06-24" @default.
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- W2378623151 date "2008-01-01" @default.
- W2378623151 modified "2023-09-25" @default.
- W2378623151 title "Local applied rapamycin inhibits intimal hyperplasia in vein graft after CABG" @default.
- W2378623151 hasPublicationYear "2008" @default.
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