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- W2378623209 abstract "Aim In order to investigate the effects and mechanisms of hydroxymethyl-furfural(HMF),an active component extracted from Cornus officinalis,on nerve cell damage induced by sodium azide(NaN3),a specific inhibitor of mitochondria respiratory chain complex IV.Methods Different concentrations of HMF were incubated with human neuroblastoma cell line SH-SY5Y cells for 24 h,then exposed to 50 mmol·L-1 sodium azide for 4 h.Cell viability was measured by MTT method and lactic dehydrogenase(LDH)leakage rate.The mitochondria membrane potential and immunofluorecence-stained cytoskeleton(microtubules and microfilaments)were observed by confocal microscopy.The expression of β-amyloid(Aβ)was measured by immuno-cytochemistry.Results Pre-incubation of HMF(12.5～200 mg·L-1)with SH-SY5Y cells antagonized the decrease in cell viability and mitochondria membrane potential induced by sodium azide.HMF improved the morphology of neurons,restored the damaged structures of microtubules and microfilaments to normal,and decreased the over-expressions of the intracellular Aβ.Conclusion HMF could protect nerve cells against cell injury induced by mitochondrial deficiency,and its mechanisms might be related to the protection of cytoskeleton and a decrease of intracellular Aβ,suggesting that HMF might play a potential role in treating Alzheimers disease and other neurodegenerative diseases." @default.
- W2378623209 created "2016-06-24" @default.
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- W2378623209 date "2008-01-01" @default.
- W2378623209 modified "2023-09-22" @default.
- W2378623209 title "Effects and mechanisms of hydroxymethyl-furfural on nerve cell injury induced by sodium azide" @default.
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