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- W2378623426 abstract "Objective To investigate the influence of iodine nutrition status and HLA- DRB1*0301、and DQB1*0602 alleles on the pathogenesis of autoimmune thyroid diseases in Shandong coastal area.Methods The HLA- DRB1*0301 and DQB1*0602 alleles were detected by polymerase chain reaction with sequence-specific primers(PCR-SSP) in 90 patients with GD and 43 patients with HT,as well as 90 health controls.The urine iodine concentration was determined by national standard method.Results The median value of urinary iodine of GD and HT patients was significantly higher than that of control group in Shandong seashore areas (P0.05).In the subjects of DRB1*0301 allele (-),the median value of urinary iodine in GD and HT patients with hyperthyroidism was significantly higher than that in control group(P0.05).In the subjects of DQB1*0602(+),the median value of urinary iodine in GD and HT patients was significantly higher than that in control group (P0.05).The logarithm of urinary iodine and DRB1*0301 were positive correlated with GD and HT by multiple Logistic regression analysis;DQB1*0602 was negative correlated with GD and HT.Conclusion The intake of iodine was higher among the patients of GD and HT in this area.Iodine,HLA-DRB1*0301 and DQB1*0602 allele have cooperative effect on the pathogenesis of GD and HT." @default.
- W2378623426 created "2016-06-24" @default.
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- W2378623426 date "2004-01-01" @default.
- W2378623426 modified "2023-09-23" @default.
- W2378623426 title "The influence of iodine nutrition status and HLA-DRB1*0301、and DQB1*0602 alleles on the pathogenesis of autoimmune thyroid diseases in Shandong coastal area" @default.
- W2378623426 hasPublicationYear "2004" @default.
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