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- W2378623456 abstract "AIM: To observe the influences of propofol anesthesia on the release of noradrenaline (NA)and α 2 NA receptor inhibitor yohimbine in rat hippocampus so as to identify the mechanisms of central noradrenaline in propofol anesthesia. METHODS: Twenty adult male SD rats were divided randomly into 2 groups. In group A, the rats were infused intravenously (IV) with propofol at a rate of 10 mg/(kg·h) for 45 min and 60 mg/(kg·h) for 45 min and in group B, the rats were given yohimbine 0.5 mg/kg intraperitoneally and were infused IV with propofol as did group A. The release of NA in the extra cellular liquid of hippocampus was quantified before propofol anesthesia, in propofol administration and after propofol administration by in vivo microdialysis technique. RESULTS: Compared with those of the group A, the NA levels in hippocampus of group B changed significantly during the whole anesthesia course, with the highest release being (0.19± 0.02) μg/15 min and the lowest release being (0.13±0.03) μg/15 min. The NA levels in group A changed steadily [from (0.16±0.01) μg/15 min to (0.14±0.02) μg/15 min], ( P 0.05). CONCLUSION: Propofol anesthesia can inhibit the NA release in hippocampus but yohimbine increases NA release in hippocampus in propofol anesthesia." @default.
- W2378623456 created "2016-06-24" @default.
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- W2378623456 date "2004-01-01" @default.
- W2378623456 modified "2023-09-23" @default.
- W2378623456 title "Effects of propofol anesthesia on noradrenaline release in rat hippocampus" @default.
- W2378623456 hasPublicationYear "2004" @default.
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