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- W2378623637 abstract "Objective To investigate the dynamic changes of HIF-1α in intracerebral hemorrhage(ICH) model rats and the influence of rhEPO on it.Methods The model of ICH in rats was established by intracerebral injection of autogenous blood,then the models of rat with ICH were divided into three groups,sham-operation group,model group and intervention group.The expressions of HIF-1α in cerebral tissue around the hemorrhagic focus and the normal cerebral tissue at different time points and different groups after ICH were detected by SP immunohistochemistry.Results The expression of the HIF-1 was gradually increased within 72h after intracerebral hemorrhage and reached peak at 72h.After that the expression of the HIF-1 was gradually decreased,and there were significant differences in different time points(P0.01).The positive expression rate of the HIF-1 after intervened by rhEPO was significantly decreased at different time points,as compared with that in model group(P0.01).Conclusion There are certain change rules in the expression of HIF-1a after intracerebral hemorrhage.And rhEPO can significantly reduce the expression of HIF-1α." @default.
- W2378623637 created "2016-06-24" @default.
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- W2378623637 date "2009-01-01" @default.
- W2378623637 modified "2023-09-24" @default.
- W2378623637 title "The dynamic changes of HIF-1α in intracerebral hemorrhage rats and the influence of rhEPO on it" @default.
- W2378623637 hasPublicationYear "2009" @default.
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