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- W2378623860 abstract "Platelet-derived growth factors (PDGFs) exert their cellular effects through their receptors (PDGFRs). PDGF and PDGFR have been implicated in the pathogenesis of a number of tumor types and play important roles in angiogenesis. Tumor growth can be promoted by PDGF via autocrine stimulation of malignant cells, overexpression or overactivation of PDGFRs, or stimulation of angiogenesis within the tumor. PDGFR blockade may also lower the interstitial fluid pressure within solid tumors and enhance drug delivery. These mechanisms suggest that PDGFR antagonists play possible and feasible therapeutic roles in the treatment of cancer, alone and in combination with chemotherapy or other targeting agents. Due to the success of PDGFR antagonist imatinib developments during the last years, the interests for PDGFRs as cancer drug targets will be dramatically improved." @default.
- W2378623860 created "2016-06-24" @default.
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- W2378623860 date "2006-01-01" @default.
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- W2378623860 title "Platelet-derived growth factor receptor and cancer" @default.
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