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- W2378623958 abstract "OBJECTIVE To evaluate effect of Mycobacterium vaccae (M. vaccae) in the prophylactic treatment for latent tuberculosis infection (LTBI). METHODS PPD test and chest X-ray were carried out among college freshmen to screen LTBI, then those LTBI students were randomly divided into control group, chemotherapy group and M. vaccae group. 660 individuals from each group were randomly picked out, then incidence of tuberculosis was followed up for 4 years approved by the Ethices Committee of our center. RESULTS Incidence rate in the control group was 3.48% (23/660); The incidence rate in the chemotherapy group was 0. 61% (4 / 660); The incidence rate in the M.vaccae group was 0.30% (2/660). M. vaccae group and chemotherapy group had no significant difference in incidence of TB (χ2=0.17, P﹥0.05), but they had significant differences from control group (M. vaccae group χ2=16.30, P﹤0.05; chemotherapy group χ2=12.25, P﹥0.05). Protection rate was 82.6% in chemotherapy group (χ2=12.25, P﹥0.05) and it was 91.3% in M. vaccae group. Complete treatment rate in the M. vaccae group (93.48%) was significantly higher than complete treatment rate in the chemical treatment group (59.7%) with statistically significant differences (χ2=210.12, P﹤0.05). CONCLUSION M. vaccae prophylactic treatment may be benefit for LTBI to reduce developing tuberculosis. Its effect has no significant difference with chemotherapy , but the adverse reaction rate is significantly lower than the chemotherapy." @default.
- W2378623958 created "2016-06-24" @default.
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- W2378623958 date "2013-01-01" @default.
- W2378623958 modified "2023-09-27" @default.
- W2378623958 title "The effect evaluation on Mycobacterium vaccae in the prophylactic treatment for latent tuberculosis infection" @default.
- W2378623958 hasPublicationYear "2013" @default.
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