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- W2378626846 abstract "Objective: To isolate the secondary metabolites from the fermentation broth and mycelium of an endophytic fungi BX- 9( Penicillium sp.) isolated from Pinellia ternate( Thunb.) and detect the biological activity of these secondary metabolites. Methods: The strain BX- 9 was fermented in PDB culture,and fermentation broth was extracted by ethyl acetate,and the mycelia of endophytic were extracted in methanol for two times. The chemical constituents of the strain BX- 9 were isolated by variety of chromatographyic methods. The ACh E inhibitory and antitumor activity was determined by modified Ellman's method and MTT method. Results: Seven compounds were isolated from the fermentation broth and mycelium of endophytic fungi from Pinellia ternate and they were identified as 2- Hydroxy- 14- tricosenvic acid( 1),[4,6,8,22- tetraen- 3- one- ergostane]( 2),Ergosterol( 3),Ergosterol peroxide( 4),( +)- Brefeldin A( 5),7- oxobrefeldin A( 6),4- epi- Brefeldin A( 7). All of the compounds had no ACh E inhibitory activity.Compounds( 3 ~ 6) had a remarkably antitumor activity against Hela,7721,HL60. Conclusion: It is possible to isolate antitumor compounds from endophytic fungi of Pinellia ternate and the strain BX- 9 can produce large numbers of brefeldin A." @default.
- W2378626846 created "2016-06-24" @default.
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- W2378626846 date "2015-01-01" @default.
- W2378626846 modified "2023-09-24" @default.
- W2378626846 title "The Secondary Metabolites Isolated from One Endophytic Fungi of Pinellia Ternate and Biological Activity" @default.
- W2378626846 hasPublicationYear "2015" @default.
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