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- W2378627051 abstract "Objective To determine the distribution of prothrombin gene polymorphism(G20210A) and explore the relationship between the polymorphism and breast and gastric cancer. Methods Peripheral blood was collected from 254 controls,53 patients with breast cancer and 34 patients with gastric cancer.Polymerase chain reaction(PCR) combined with restriction enzyme digestion and electrophoresis was used to detect prothrombin G20210A mutations.Results The distribution of prothrombin G20210A gene mutation in controls and patients with breast cancer and gastric cancer was in accordance with Hardy-Weinberg laws.The frequencies of prothrombin 20210A gene in control,breast cancer and gastric cancer were 1.23%,0.94% and 1.47% respectively.The rate of prothrombin 20210A gene mutation was found to be higher in gastric cancer when compared with controls(0.0147 vs 0.0123).However,statistical significance was not found between controls and the patients with breast cancer.Conclusion Prothrombin 20210A gene mutation may increase genetic susceptibility of gastric cancer." @default.
- W2378627051 created "2016-06-24" @default.
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- W2378627051 date "2005-01-01" @default.
- W2378627051 modified "2023-09-27" @default.
- W2378627051 title "Study on the Association of Prothrombin Gene Polymorphism(G20210A) with Breast Cancer and Gastric Cancer" @default.
- W2378627051 hasPublicationYear "2005" @default.
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